What we believe
The gut plays an essential role in infant health and well-being. The gut needs to develop and mature sufficiently in early life to ensure a first line of defence against threats from the external environment
Kelly D, King T, Aminov R. Importance of microbial colonization of the gut in early life to the development of immunity. Mutat Res Mol Mech Mutagen. 2007;622(1):58-69. doi:https://doi.org/10.1016/j.mrfmmm.2007.03.011 ;
to support microbiota development,
Zhuang, L., Chen, H., Zhang, S., Zhuang, J., Li, Q., & Feng, Z. (2019). Intestinal Microbiota in Early
Life and Its Implications on Childhood Health. Genomics, Proteomics & Bioinformatics, 17(1), 13–25.
https://doi.org/10.1016/j.gpb.2018.10.002
proper digestion and absorption of nutrients;
Hamosh M. Digestion in the Newborn. Clin Perinatol. 1996;23(2):191-209. doi:https://doi.org/10.1016/S0095-5108(18)30238-0
and to ensure adequate development of the immune system
Martin, R., Nauta, A. J., Ben Amor, K., Knippels, L. M. J., Knol, J., & Garssen, J. (2010). Early life: Gut microbiota and immune development in infancy. Beneficial Microbes. https://doi.org/10.3920/BM2010.0027
.Good gut health relies on gut colonisation by beneficial micro-organisms during the establishment of the infant gut microbiota.
At FrieslandCampina Ingredients, we believe that delivering a larger variety of non-digestible oligosaccharides—a combination of GOS and HMOs—can be of key importance for the establishment of the gut microbiota and its metabolism, thereby feeding into many different health aspects in early life and beyond.
So how does good gut health in infants offer benefits throughout life? We recognize four benefit areas: 1) immune health; limiting the ability of pathogens to colonise the gut, supporting the healthy development and function of the immune system
Arrieta, M.C., Stiemsma, L.T., Amenyogbe, N. & Brown, E.M. The intestinal microbiome in early life: health and disease. Front Immuno. 2014;5;5:427.
. 2) digestive comfort; stimulating the growth of Bifidobacteria, so promoting the production of short-chain fatty acids (SCFAs) and improving stool consistency and regularity of bowel movements
Williams T, Choe Y, Price P, et al. Tolerance of formulas containing prebiotics in healthy, term infants. J Pediatr Gastroenterol Nutr. Published online 2014. doi:10.1097/MPG.0000000000000513
. 3) brain development and emotional wellbeing; influencing (directly or indirectly) neuro-cognitive development and brain function, through specific gut-brain pathways
Ratsika, A., Codagnone, M. C., O’mahony, S., Stanton, C., & Cryan, J. F. (2021). Priming for life: Early life nutrition and the microbiota-gut-brain axis. In Nutrients. https://doi.org/10.3390/nu13020423
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H., & Knickmeyer, R. C. (2018). Infant Gut Microbiome Associated With Cognitive Development. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2017.06.021
. 4) healthy growth; supporting key mineral absorption for healthy growth
Skrypnik, K., & Suliburska, J. (2018). Association between the gut microbiota and mineral metabolism. In Journal of the Science of Food and Agriculture. https://doi.org/10.1002/jsfa.8724
Whisner, C. M., & Castillo, L. F. (2018). Prebiotics, Bone and Mineral Metabolism. In Calcified Tissue International. https://doi.org/10.1007/s00223-017-0339-3
.