Lactoferrin

Lactoferrin is a natural, iron-binding glycoprotein that is present in human milk in high concentrations

Manzoni, P., Dall’Agnola, A., Tomé, D., Kaufman, D. A., Tavella, E., Pieretto, M., Messina, A., De Luca, D., Bellaiche, M., Mosca, A., Piloquet, H., Simeoni, U., Picaud, J. C., & Del Vecchio, A. (2018). Role of Lactoferrin in Neonates and Infants: An Update. American Journal of Perinatology, 35(6), 561–565. https://doi.org/10.1055/s-0038-1639359.
Yang, Z., Jiang, R., Chen, Q., Wang, J., Duan, Y., Pang, X., Jiang, S., Bi, Y., Zhang, H., Lönnerdal, B., Lai, J., & Yin, S. (2018). Concentration of lactoferrin in human milk and its variation during lactation in different Chinese populations. Nutrients, 10(9), 1–10. https://doi.org/10.3390/nu10091235



. It has also been identified in a number of mammalian species, including in cow’s milk. Lactoferrin can be isolated from cow’s milk and can be added to infant and young child formulations.

Lactoferrin helps to support a normal immune response against viruses and bacteria

Donovan, S. M. (2016). The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective. Journal of Pediatrics, 173, S16–S28. https://doi.org/10.1016/j.jpeds.2016.02.072
Elzoghby, A. O., Abdelmoneem, M. A., Hassanin, I. A., Abd Elwakil, M. M., Elnaggar, M. A., Mokhtar, S., Fang, J. Y., & Elkhodairy, K. A. (2020). Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand. Biomaterials, 263(August), 120355. https://doi.org/10.1016/j.biomaterials.2020.120355



. It can thereby reduce the risk of gastro-intestinal and respiratory tract infection in infants and young children

Chen, K., Chai, L., Li, H., Zhang, Y., Xie, H. M., Shang, J., Tian, W., Yang, P., & Jiang, A. C. (2016). Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition, 32(2), 222–227. https://doi.org/10.1016/j.nut.2015.08.010
Gao, Y., Hou, L., Lu, C., Wang, Q., Pan, B., & Wang, Q. (2020). Enteral Lactoferrin Supplementation for Preventing Sepsis and Necrotizing Enterocolitis in Preterm Infants : A Meta ‑ Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Frontiers in Pharmacology, 11, 1186. https://doi.org/10.3389/fphar.2020.01186
King, J. C., Cummings, G. E., Guo, N., Trivedi, L., Readmond, B. X., Keane, V., Feigelman, S., & De Waard, R. (2007). A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. Journal of Pediatric Gastroenterology and Nutrition, 44(2), 245–251. https://doi.org/10.1097/01.mpg.0000243435.54958.68
Li, F., Wu, S. S., Berseth, C. L., Harris, C. L., Richards, J. D., Wampler, J. L., Zhuang, W., Cleghorn, G., Rudolph, C. D., Liu, B., Shaddy, D. J., & Colombo, J. (2019). Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2019.08.030
Tarnow-Mordi, W. O., Abdel-Latif, M. E., Martin, A., Pammi, M., Robledo, K., Manzoni, P., Osborn, D., Lui, K., Keech, A., Hague, W., Ghadge, A., Travadi, J., Brown, R., Darlow, B. A., Liley, H., Pritchard, M., Kochar, A., Isaacs, D., Gordon, A., … Espinoza, D. (2020). The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. The Lancet Child and Adolescent Health, 4(6), 444–454. https://doi.org/10.1016/S2352-4642(20)30093-6



. Lactoferrin has also been demonstrated to play an immune-modulatory role

Kruzel, M. L., Zimecki, M., & Actor, J. K. (2017). Lactoferrin in a context of inflammation-induced pathology. In Frontiers in Immunology (Vol. 8, Issue NOV). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.01438



.

Vivinal® Lactoferrin is produced not from whey but from high-quality fresh milk that we receive daily, directly from FrieslandCampina’s member farmers. Our careful extraction method results in consistent high purity, and our spray-drying process creates a powder with more homogenous and smaller particle size distribution compared to alternatives in the market. Vivinal® Lactoferrin is manufactured under infant-formula grade conditions.

• Helps to support a normal immune response against viruses and bacteria
  
  Donovan, S. M. (2016). The Role of Lactoferrin in Gastrointestinal and Immune Development and Function: A Preclinical Perspective. Journal of Pediatrics, 173, S16–S28. https://doi.org/10.1016/j.jpeds.2016.02.072
  Elzoghby, A. O., Abdelmoneem, M. A., Hassanin, I. A., Abd Elwakil, M. M., Elnaggar, M. A., Mokhtar, S., Fang, J. Y., & Elkhodairy, K. A. (2020). Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand. Biomaterials, 263(August), 120355. https://doi.org/10.1016/j.biomaterials.2020.120355
  
  
  
•  Can reduce risk of infections
  
  Chen, K., Chai, L., Li, H., Zhang, Y., Xie, H. M., Shang, J., Tian, W., Yang, P., & Jiang, A. C. (2016). Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial. Nutrition, 32(2), 222–227. https://doi.org/10.1016/j.nut.2015.08.010
  Gao, Y., Hou, L., Lu, C., Wang, Q., Pan, B., & Wang, Q. (2020). Enteral Lactoferrin Supplementation for Preventing Sepsis and Necrotizing Enterocolitis in Preterm Infants : A Meta ‑ Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Frontiers in Pharmacology, 11, 1186. https://doi.org/10.3389/fphar.2020.01186
  King, J. C., Cummings, G. E., Guo, N., Trivedi, L., Readmond, B. X., Keane, V., Feigelman, S., & De Waard, R. (2007). A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. Journal of Pediatric Gastroenterology and Nutrition, 44(2), 245–251. https://doi.org/10.1097/01.mpg.0000243435.54958.68
  Li, F., Wu, S. S., Berseth, C. L., Harris, C. L., Richards, J. D., Wampler, J. L., Zhuang, W., Cleghorn, G., Rudolph, C. D., Liu, B., Shaddy, D. J., & Colombo, J. (2019). Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial. Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2019.08.030
  Tarnow-Mordi, W. O., Abdel-Latif, M. E., Martin, A., Pammi, M., Robledo, K., Manzoni, P., Osborn, D., Lui, K., Keech, A., Hague, W., Ghadge, A., Travadi, J., Brown, R., Darlow, B. A., Liley, H., Pritchard, M., Kochar, A., Isaacs, D., Gordon, A., … Espinoza, D. (2020). The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. The Lancet Child and Adolescent Health, 4(6), 444–454. https://doi.org/10.1016/S2352-4642(20)30093-6
  
  
  
• Can have an immunomodulatory effect
  
  Kruzel, M. L., Zimecki, M., & Actor, J. K. (2017). Lactoferrin in a context of inflammation-induced pathology. In Frontiers in Immunology (Vol. 8, Issue NOV). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.01438
  
  
  

We are proud to be market leader with more than 25 years of experience in lactoferrin production. We offer the support of our reliable and robust methods to analyse and quantify the composition of your infant milk formula, ensuring the right balance of lactoferrin and other ingredients. Vivinal® Lactoferrin complies with both Chinese and EU legislation.